Formation Constants of Hydrazine Derivative with Co, Ni, Zn, Cd and its Antimicrobial Evaluation
Formation Constants and Antimicrobial Evaluation
Keywords:Formation constant, Job’s method, Antimicrobial activities
Formation constants of hydrazine derivative with Co, Ni, Zn and Cd were determined by Job’s methods of continuous variation using UV/Visible spectrophotometer at 350nm, 392nm and 420nm. The highest values of formation constants were found as 8.771 for Co, Ni and Zn; whereas the lowest formation constant was found as 6.678 for Cd. The evaluation of antimicrobial activities revealed intermediate results against Escherichia coli, Staphylococcus aureus and Candida albicans
Asri, J., M. M. Aly, N. E. Eltayeb & A. B. Bandar. Synthesis of symmetrical and asymmetrical azines from hydrazones and/or ferrocenecarboxaldehyde as potential antimicrobial-antitumor agents. Journal of Molecular Structure 1164: 1-8 (2018).
Jayabharathi, J., V. Thanikachalam, A. Thangamani & M. Padmavathy. Synthesis, AM-1 calculation, and biological studies of thiopyran-4-one and their azine derivatives, Medicinal Chemistry Research 16 (6): 266-279 (2007).
Veena, K., M. Ramaiah, G. K. Vanita, T. S. Avinash & V. P. Vaidya. Synthesis of symmetrical and asymmetrical azines encompassing naphtho [2,1-b] furan by a novel approach. E-Journal of Chemistry 8(1): 354-360 (2011).
Adedibu, C. T., A. O. Joshua & K. O. Gabriel. Spectrophotometric study of stability constants of dapsone – Cu (II) complex at different temperatures. J. Pharmacy Research 4(1): 241-244 (2011).
Gulzar, A., Q. Ali, S. M. Shah, A. Asghar & I. U. Bajwa, Synthesis, characterization and determination of formation constants of 1, 2 – bis (2,5 - dimethoxybenzylidene) hydrazine with zinc (II) and nickle (II) salts by visible spectrophotometer. Sci. Int. (Lahore) 28(3): 2489-2492 (2016).
Syed, A. T., M. H. S. Wattoo, S. Sarwar, F. H. Wattoo, A. B. Ghanghro & J. Iqbal. Spectrophotometric study of stability constants of Ni (II) – Famotidine complex at different temperature. Arabian Journal of Chemistry 3(2): 206-210 (2010).
Gemechu Z. B., T. Kebede, E. G. Demissie & G. Workeneh. Spectrophotometric study on the stability constants and thermodynamic parameters of Zn+2, Cd+2 and Hg+2 complexes with imino thiazolidinone. African Journal of Pure and Applied Chemistry 9(8): 175-183 (2015).
Ibrahim, M. B. & A. Moyosore. Spectrophotometric study of stability constants of Co (II), Ni (II) and Cu (II) complexes of 2, 2 – bipyridine at different temperatures. Chem. Search Journal 5(1): 51-55 (2014).
Parihar M. S. & F. Khan. Stability constants and thermodynamic parameters of cadmium complexes with sulfonamides and cephapirin. Ecletica Quimica 33(1): 29-34 (2008).
Naaliya, J. & H. N. Aliyu. Potentiometric titration with sodium hydroxide for determination of stability constants of iron, manganese, cobalt and nickel complexes of glycine in aqueous solution. Bayero Journal of Pure and Applied Sciences 3(2): 101-106 (2010).
Al-Ahdal Z., S. Jadhav, M. Farooqui & M. J. Rai. Stability constants of transition metal complexes with pharmacologically active ligand were studied by pH meter. International Journal of ChemTech Research 11(11): 211-216 (2018).
Payehghadr, M., A. B. Akbar & A. Fraydoun. Spectrophotometric and conductometric studies of the thermodynamics of complexation of Zn2+ , Cu2+, Co2+, Ni2+ and Cd2+ ions with a new schiff base ligand in acetonitrile solution. African Journal of Pure and Applied Chemistry 3(5): 92-97 (2009).
Sandra, S. K., C. R. Blaga, B. T. Zoran & B. I. Slavica. Spectrophotometric study of Co (II), Ni (II), Cu (II), Zn (II), Pd (II) and Hg (II) complexes with isatin – B – thisemicarbazone at 30°C. J. Serb. Chem. Soc. 72(10): 975-981 (2007).
Eugenijus, N., S. Ina, J. Aldona & P. Kestutis. Cu (II) complex formation with pentaethylene hexamine: determination of stability constants by the ligand displacement method. ChemiJa 22(2): 131-137 (2011).
Perez, C., M. Paul & P. Bazerque. An antibiotic assay by the agar well diffusion method. Acta Biologiae et Medicinae Experimentalis 15: 113-115 (1990).
Burt, S. Essential oils: their antibacterial properties and potential applications in foods: A review. Int. J. Food Microbiol. 94(3): 223-253 (2004).
Johnson, T. & C. Case. “Chemical Methods of Control,” adapted from Laboratory Experiments in Microbiology, Brief Edition, 4th ed. Redwood City, CA: Benjamin/Cummings Publishing Co. (1995). Available online from The National Health Museum, Access Excellence Activities Exchange [accessed September 11, 2006].