A Wonder Plant Aloe vera L. (Liliaceae): An Overview of its Folk Traditional Uses, Phytoconstituents, Biological Activities, and Cosmaceutical Applications


  • Maira Batool Department of Botany, Government Queen Mary Graduate College, Lahore 54000, Punjab Pakistan
  • Malaika Khan Department of Botany, Government Queen Mary Graduate College, Lahore 54000, Punjab Pakistan
  • Maria Mubarak Department of Botany, Government College University, Lahore 54000, Punjab Pakistan
  • Adil Hussain Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex Ferozepur Road Lahore 54600, Punjab Pakistan
  • Muafia Shafiq Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex Ferozepur Road Lahore 54600, Punjab Pakistan
  • Shamma Firdous Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex Ferozepur Road Lahore 54600, Punjab Pakistan
  • Asma Saeed Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex Ferozepur Road Lahore 54600, Punjab Pakistan




Aloe vera, Biological activities, Cosmeceutical uses, Folk traditional uses, Lililaceae, Phytoconstituents, Wonder plant


Aloe vera L. (Lililaceae) bears various medicinal applications that likely date back more than a thousand years ago. The current review provides an overview of the folk traditional uses, phytochemistry, biological activities, and cosmaceutical applications of the A. vera plant to date. The data have been retrieved from different scientific databases, including PubMed-Medline, Researchgate, Google Scholar, Science Direct, Scopus, SciELO, Taylor & Francis, Web of Science, books, conference papers, Masters and Ph.D. dissertations. As per the collected data of this review, almost 40 active phytoconstituents in A. vera have been reported so far with varying concentrations. Ethnobotanical data displayed that A. vera is still used as traditional medicine among communities against more than 20 different health-related problems. The DPPH, FRAP, TAC, and ABTS assays were commonly employed where A. vera extracts showed varying antioxidant activities against reactive oxygen species (ROS). Data on the biological activities showed A. vera plant extracts with remarkable anti-inflammatory activities through the inhibition of TNF-α and prostaglandin E2 factors and also exerts anti-diabetic activity against type 1 and type 2 diabetes. As per the collected data of this review, A. vera extracts have been reported with anti-microbial activities against more than 12 bacterial and 7 fungal strains and also obstruct the uncontrollable proliferation of specific types of cancer cells like HCT-116, HepG2, HeLa, A549, and MCF-7. Conclusively, A. vera possesses wide-ranging applications in the treatment of various diseases. However, more controlled investigations and clinical trials with the elucidation of the mechanism of action activities are prerequisites in the future to substantiate the outcomes and efficacies of A. vera under different circumstances. Any toxic effects of A. vera if associated with specific extracts or compounds should be addressed for safer consumption of Aloe-based food and cosmetic products.


P. Danish, Q. Ali, M.M. Hafeez, and A. Malik. Antifungal and antibacterial activity of Aloe vera plant extract. Biological and Clinical Sciences Research Journal (1): 2708-2261(2020).

F. Sayar, A.H. Farahmand, and M. Rezazadeh. Clinical efficacy of Aloe vera toothpaste on periodontal parameters of patients with gingivitis—A randomized, controlled, singlemasked clinical trial. The Journal of Contemporary Dental Practice 22(3): 242-247 (2021).

N. Asthana, K. Pal, A.A. Aljabali, M.M. Tambuwala, F.G. de Souza, and K. Pandey. Polyvinyl alcohol (PVA) mixed green–clay and aloe vera based polymeric membrane optimization: Peel-off mask formulation for skin care cosmeceuticals in green nanotechnology. Journal of Molecular Structure 1229: 129592 (2021).

A. Farid, H. Haridyy, S. Ashraf, S. Ahmed, and G. Safwat. Aloe vera gel as a stimulant for mesenchymal stem cells differentiation and a natural therapy for radiation induced liver damage. Journal of Radiation Research and Applied Sciences 15(3): 270-278 (2022).

R.P. Shirsat. Ethnomedicinal uses of some common bryophytes and pteridophytes used by tribals of Melghat region (Ms), India. Ethnobotanical Leaflets 2008(1): 92 (2008).

W. Hussain, L. Badshah, M. Ullah, M. Ali, A. Ali, and F. Hussain. Quantitative study of medicinal plants used by the communities residing in Koh-e-Safaid Range, northern Pakistani-Afghan borders. Journal of Ethnobiology and Ethnomedicine 14(1): 1-18 (2018).

D. Ali, A.H. Shah, K.R. Khan, M. Farooq, M. Hussain, G.M. Shah, and A. Mehmood. Ethnomedicinal exploration of tracheophytes of Hangrai, district Mansehra, Khyber Pakhtunkhwa, Pakistan. Journal of Biodiversity and Environmental Sciences 14(1): 105-120 (2019).

E. Hernández-Rodríguez, and C. Delgadillo-Moya. The ethnobotany of bryophytes in Mexico. Botanical Sciences 99(1): 13-27 (2021).

W. Tang, G. Eisenbrand. Chinese drugs of plant origin: chemistry, pharmacology, and use in traditional and modern medicine. Springer Science & Business Media 27:3145-543210 (2013).

A.K. Shakya. Medicinal plants: Future source of new drugs. International Journal of Herbal Medicine 4(4): 59-64 (2016).

S. Madani, B. Amel, H. Noui, S. Djamel, and H. Hadjer. An ethnobotanical survey of galactogenic plants of the Berhoum District (M’sila, Algeria). Journal of Intercultural Ethnopharmacology 6(3): 311 (2017).

N. Jadid, E. Kurniawan, C.E.S. Himayani, I. Prasetyowati, K.I. Purwani, W. Muslihatin, D. Hidayati, and I.T.D. Tjahjaningrum. An ethnobotanical study of medicinal plants used by the Tengger tribe in Ngadisari village, Indonesia. Plos One 15(7): e0235886 (2020).

F. Zatout, B. Benarba, A. Bouazza, B. Babali, N.N. Bey, and A. Morsli. Ethnobotanical investigation on medicinal plants used by local populations in Tlemcen National Park (extreme North West Algeria). Mediterranean Botany 15(30): 12 (2021).

G. Dastagir, S. Bibi, N. U. Uza, R.W. Bussmann, and I. Ahmad. Microscopic evaluation, ethnobotanical and phytochemical profiling of a traditional drug Viola odorata L. from Pakistan. Ethnobotany Research and Applications 25: 1-24 (2023).

M. Saxena, J. Saxena, R. Nema, D. Singh, and A. Gupta. Phytochemistry of medicinal plants. Journal of pharmacognosy and phytochemistry 1(6) (2013).

A. Hussain, M. Q. Hayat, S. Sahreen, Q.U. Ain, and S.A.I. Bokhari. Pharmacological promises of genus Artemisia (Asteraceae): a review. Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences 54(4): 265-287 (2017).

I. Hamdeni, I. Yangui, A. Sanaa, S. Slim, M. Louhaichi, C. Messaoud, A. Boulila, and T. Bettaieb. Aloe vera L. (Asphodelaceae): Supplementation of in-vitro culture medium with Aloe vera gel for production of genetically stable plants. South African Journal of Botany 147:1206-1213 (2022).

A. Hussain, M.Q. Hayat, and S.A.I. Bokhari. Some important species of the genus Artemisia L (Asteraceae) from northeastern (Gilgit-Baltistan) Pakistan and their folk medicinal uses. Proceedings of the Pakistan Academy of Science: B Life and Environmental Sciences 57(2): 35-48 (2020).

S. Sharma, and S. Sharma. Aloe vera: An ancient herb its components and applications. Journal of Pharmacognosy and Phytochemistry 7(6): 514-516 (2018).

E.V. Christaki, and P.C. Florou-Paneri. Aloe vera: a plant for many uses. Journal of Food Agriculture and Environment 8(2): 245-249 (2010).

D.I. Sánchez-Machado, J. López-Cervantes, R. Sendón, and A. Sanches-Silva. Aloe vera: Ancient knowledge with new frontiers. Trends in Food Science & Technology 61: 94- 102 (2017).

N.Z. Malik, M. Riaz, Q.Q. Noshad, N. Rashid, Q.U. Ain, and A. Hussain. Morphological, phytochemical and antifungal analysis of Aloe vera L. leaf extracts. Asian Journal of Agriculture and Biology 5(4): 177-187 (2017).

A.F. Nia, A.F. Sardrodi, M.M. Habibi, and S. Bahman. Morphological and physiological changes of Aloe (Aloe barbadensis Miller.) in response to culture media. International Journal of Agronomy and Agricultural Research 6(6): 100-105 (2015).

R.M. Beiu, V.F. Duma, C.A. Mnerie, A.C. Beiu, M.A. Dochia, L. Copolovici, G. Dobre, A. Bradu, and A. Podoleanu. Optical coherence tomography versus microscopy for the study of Aloe vera leaves. In: Optics, Photonics and Digital Technologies for Imaging Applications VII 12138: 60-68 (2022).

S. Bendjedid, R. Djelloul, A. Tadjine, C. Bensouici, and A. Boukhari. In vitro Assessment of Total Bioactive Contents, Antioxidant, Anti-Alzheimer and Antidiabetic Activities of Leaves Extracts and Fractions of Aloe vera. Journal of Natural Sciences 19, pp.469-485 (2020).

A. Kumar, A. Mahajan, and Z. Begum. Phytochemical screening and in vitro study of free radical scavenging activity of flavonoids of Aloe vera. Research Journal of Pharmacy and Technology 13(2): 593-598 (2020).

C.K. Nakiguli, V.J. Kosgei, J.K. Cherutoi, and J. Odda. Quantification of aloin in Aloe barbadensis Miller leaf gel and latex from selected regions of Kenya. Open Access Library Journal 9(4): 1-12 (2022).

A. Joseph, and S.J. Raj. Pharmacognostic and phytochemical properties of Aloe vera linn an overview. International Journal of Pharmaceutical Sciences Review and Research 4(2): 106-110 (2010).

O.M. Grace, S. Buerki, M. R. Symonds, F. Forest, A.E. van Wyk, G.F. Smith, R.R. Klopper, C.S. Bjorå, S. Neale, S. Demissew, and M.S. Simmonds. Evolutionary history and leaf succulence as explanations for medicinal use in Aloe and the global popularity of Aloe vera. BMC evolutionary biology 15(1): 1-12 (2015).

A. Gupta, and S. Rawat. Clinical importance of Aloe vera. Research Journal of Topical and Cosmetic Sciences 8(1): 30 (2017).

M. Tiwari, and M. Upadhayay. The medicinal plant components and applications (Aloe vera). Journal of Medicinal Plants Studies 6(3): 89-95 (2018).

R. Rahimi-Dehgolan, Z. Tahmasebi Sarvestani, S.A. Rezazadeh, and A. Dolatabadian. Morphological and physiological characters of Aloe vera subjected to saline water irrigation. Journal of herbs, spices & medicinal plants 18(3): 222-230 (2012).

E. Raphael. Phytochemical constituents of some leaves extract of Aloe vera and Azadirachta indica plant species. Global Advanced Research Journal of Environmental Science and Toxicology 1(2): 014-017 (2012).

B.B. Petrovska. Historical review of medicinal plants usage. Pharmacognosy Reviews 6:1-5 (2012).

A. Hussain. The genus Artemisia (Asteraceae): a review on its ethnomedicinal prominence and taxonomy with emphasis on foliar anatomy, morphology, and molecular phylogeny. Proceedings of the Pakistan Academy of Science: B Life and Environmental Sciences 57: 1-28 (2020a).

A. Hussain. A preliminary up-to-date review on Pakistani medicinal plants with potential antioxidant activity. RADS Journal of Biological Research and Applied Sciences 11(1):61-88 (2020b).

E. Estrada-Castillón, M. Garza-López, J.A. Villarreal-Quintanilla, M.M. Salinas-Rodríguez, B.E. Soto-Mata, H. González-Rodríguez, D.U. González-Uribe, I. Cantú-Silva, A. Carrillo-Parra, and C. Cantú-Ayala. Ethnobotany in Rayones, Nuevo León, México. Journal of Ethnobiology and Ethnomedicine 10(1): 1-13 (2014).

Y.Y. Siew, S. Zareisedehizadeh, W.G. Seetoh, S.Y. Neo, C.H. Tan, and H.L. Koh. Ethnobotanical survey of usage of fresh medicinal plants in Singapore. Journal of Ethnopharmacology 155(3): 1450-1466 (2014).

K. Manvitha, and B. Bidya. Aloe vera: a wonder plant its history, cultivation and medicinal uses. Journal of Pharmacognosy and Phytochemistry 2(5): 85-88 (2014).

A. Asase, and D. T. Yohonu. Ethnobotanical study of herbal medicines for management of diabetes mellitus in Dangme west district of southern Ghana. Journal of Herbal Medicine 6(4): 204-209 (2016).

E. F. Fongnzossie, Z. Tize, P.F. Nde, C.N. Biyegue, I.B. Ntsama, S.D. Dibong, and B.A. Nkongmeneck. Ethnobotany and pharmacognostic perspective of plant species used as traditional cosmetics and cosmeceuticals among the Gbaya ethnic group in Eastern Cameroon. South African Journal of Botany 112: 29-39 (2017).

H.M. Amir, O.M. Grace, E. Wabuyele, and M.L.K. Manoko. Ethnobotany of Aloe L.(Asphodelaceae) in Tanzania. South African Journal of Botany 122: 330-335 (2019).

O.S. Oladeji, A.P. Oluyori, D.T. Bankole, and T.Y. Afolabi. Natural products as sources of antimalarial drugs: ethnobotanical and ethnopharmacological studies. Scientifica Article ID 7076139, 22 pages (2020).

A. Roy, and S. Janbandhu. An ethnobotanical analysis on flora-medicine continuum among the tribal inhabitants of Ratnagiri and Palghar district, Maharashtra, India. Ethnobotany Research and Applications 20:1-23 (2020).

S. Abihudi. Ethnobotanical use, threat status and optimal environmental germination conditions for conservation of Aloe species in Tanzania. (2022). https://dspace.nmaist.ac.tz/handle/20.500.12479/1548

L.K. Keter, and P.C. Mutiso. Ethnobotanical studies of medicinal plants used by Traditional Health Practitioners in the management of diabetes in lower eastern Province, Kenya. Journal of Ethnopharmacology 139(1): 74-80 (2012).

M. Al-Fatimi. Ethnobotanical survey of medicinal plants in central Abyan governorate, Yemen. Journal of Ethnopharmacology 241: 111973 (2019).

R.I. Asif. Phytochemical and ethnobotanical effect of Aloe vera. NUST Journal of Natural Sciences (2021).


F.M. Mutie, L.L. Gao, V. Kathambi, P.C. Rono, P.M. Musili, G. Ngugi, G.W. Hu, and Q.F. Wang. An ethnobotanical survey of a dryland botanical garden and its environs in Kenya: the Mutomo hill plant sanctuary. Evidence-Based Complementary and Alternative Medicine 22 pages (2020). Article ID 1543831.

S.N. Babu, S. Govindarajan, M.A. Vijayalakshmi, and A. Noor. Evaluation of in vitro anti-diabetic and anti-oxidant activities and preliminary phytochemical screening of gel, epidermis and flower extract of Aloe vera. Research journal of pharmacy and technology 12(4): 1761-1768 (2019).

G. Sathyaprabha, S. Kumaravel, D. Ruffina, and P. Praveenkumar. A comparative study on antioxidant, proximate analysis, antimicrobial activity and phytochemical analysis of Aloe vera and Cissus quadrangularis by GC-MS. Journal of Pharmacy Research 3(12): 2970-2973 (2010).

D.K. Patel, K. Patel, and S.P. Dhanabal. Phytochemical standardization of Aloe vera extract by HPTLC techniques. Journal of Acute Disease 1(1): 47-50 (2012).

A. Ray, S.D. Gupta, and S. Ghosh. Evaluation of anti-oxidative activity and UV absorption potential of the extracts of Aloe vera L. gel from different growth periods of plants. Industrial Crops and Products 49: 712-719 (2013).

C.Ibe, C.C. Jacobs, C. Imo, K.U. Osuocha, and M.U. Okoronkwo. Evaluation of the antioxidant activities of Psidium guajava and Aloe vera. British Journal of Pharmaceutical Research 4(3): 397 (2014).

U. Taukoorah, and M.F. Mahomoodally. Crude Aloe vera gel shows antioxidant propensities and inhibits pancreatic lipase and glucose movement in vitro. Advances in Pharmacological and Pharmaceutical Sciences 2016 (2016).

D. Dharajiya, N. Pagi, H. Jasani, and P. Patel. Antimicrobial activity and phytochemical screening of Aloe vera (Aloe barbadensis Miller). International Journal of Current Microbiology and Applied Sciences 6(3): 2152-2162 (2017).

H. Tariq, M. Zia, S.A. Muhammad, S.A. Khan, N. Fatima, A. Mannan, A.M. Abbasi, and M. Zhang. Antioxidant, antimicrobial, cytotoxic, and protein kinase inhibition potential in Aloe vera L. BioMed Research International 14 pages (2019). Article ID 6478187.

P.U.I.A. Aida, V.S. Chedea, A.M. Levai, I.C. Bocsan, and A.D. Buzoianu. Pot Aloe vera gel–a natural source of antioxidants. Notulae Botanicae Horti Agrobotanici ClujNapoca 50(2): 12732-12732 (2022).

O.A. Wintola, and A.J. Afolayan. Phytochemical constituents and antioxidant activities of the whole leaf extract of Aloe ferox Mill. Pharmacognosy Magazine 7(28):325-33 (2011).

S. Kumar, A. Yadav, M. Yadav, and J.P. Yadav. Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm. f. BMC Research Notes 10(1): 1-12 (2017).

M. Cardarelli, Y. Rouphael, M. Pellizzoni, G. Colla, and L. Lucini. Profile of bioactive secondary metabolites and antioxidant capacity of leaf exudates from eighteen Aloe species. Industrial Crops and Products 108: 44-51(2017).

D. Mahendiran, G. Subash, D. Arumai Selvan, D. Rehana, R. Senthil Kumar, and A. Kalilur Rahiman. Biosynthesis of zinc oxide nanoparticles using plant extracts of Aloe vera and Hibiscus sabdariffa: Phytochemical, antibacterial, antioxidant and anti-proliferative studies. Bio Nano Science 7(3): 530-545 (2017).

S.F. Faid. Phytochemical Constituents from Aloe vera leaves and garden grass seeds and their utilization as anticancer activity. International Journal of Engineering Research & Technology 8(11) (2019).

I.Kahramanoğlu, C. Chen, J. Chen, and C. Wan. Chemical constituents, antimicrobial activity, and food preservative characteristics of Aloe vera gel. Agronomy, 9(12), p.831 (2019).

R.B. Usman, M. Adamu, I.M. Isyaku, and H.A. Bala. Quantitative and qualitative phytochemicals and proximate analysis of Aloe vera (Aloe barbadensis miller). International Journal of Advanced Academic Research 6(1): 95-104 (2020).

F. Iqbal, and A. Ahmed. Antibacterial activity of Aloe barbadensis Mill. Polish Journal of Environmental Studies 30(4): 3637-3643 (2021).

S. Bendjedid, I. Bazine, A. Tadjine, R. Djelloul, A. Boukhari, and C. Bensouici. Analysis of phytochemical constituents by using LC-MS, antifungal and allelopathic activities of leaves extracts of Aloe vera. Jordan Journal of Biological Sciences 15(1): 21-28 (2022).

M.M. Arsene, P.I. Viktorovna, G.V. Sergei, F. Hajjar, Y.N. Vyacheslavovna, Z.A. Vladimirovna, V.E. Aleksandrovna, S.A. Nikolayevich, and N. Sachivkina. Phytochemical analysis, antibacterial and antibiofilm activities of Aloe vera aqueous extract against selected resistant gram-negative bacteria involved in urinary tract infections. Fermentation 8(11): 626 (2022).

P.K. Mukherjee, N.K. Nema, N. Maity, K. Mukherjee, and R.K. Harwansh. Phytochemical and therapeutic profile of Aloe vera. Journal of Natural Remedies 1-26 (2014).

S. Kumar, M. Yadav, A. Yadav, P. Rohilla, and J.P. Yadav. Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India. BMC Complementary and Alternative Medicine 17(1): 1-10 (2017).

P. Goyal, R. Chhabra, and S. Kaur. Aloe vera: Phytochemical composition and its pharmacological properties. Indian Journal of Agricultural Biochemistry 35(1): 15-19 (2022).

A.M. Al-Wajih, A.M. El-Shaibany, S.M. Raweh, and M.M. El–Aasser. Preliminary phytochemical screening for various secondary metabolites, quantitative and qualitative analysis of Yemeni Aloe vera and Aloe vacillans flower extracts. GSC Biological and Pharmaceutical Sciences 21(2): 202-210 (2022).

E. Multia. Potential and utilization of water extracts from spruce bark. School of Chemical Engineering (2018).


V. Uivarosi, A.C. Munteanu, and G.M. Nițulescu. An overview of synthetic and semisynthetic flavonoid derivatives and analogues: perspectives in drug discovery. Studies in Natural Products Chemistry 60(2019): 29-84 (2019).

D. Tsimogiannis, and V. Oreopoulou. Classification of phenolic compounds in plants. In: Polyphenols in plants 263-284 (2019). Academic Press.

J. Vaca, F. Salazar, A. Ortiz, and E. Sansinenea. Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study. The Journal of Antibiotics 73(11): 798-802 (2020).

L.S. Lai, S.T. Chou, and W.W. Chao. Studies on the antioxidative activities of Hsian-tsao (Mesona procumbens Hemsl) leaf gum. Journal of Agricultural Food Chemistry 49:963-8 (2001).

K. Tkacz, A. Wojdyło, I.P. Turkiewicz, L. Bobak, and P. Nowicka. Anti-oxidant and anti-enzymatic activities of Sea buckthorn (Hippophae rhamnoides L.) fruits modulated by chemical components. Antioxidants (Basel) 8(12): 618 (2019).

B. Benzidia, M. Barbouchi, H. Hammouch, N. Belahbib, M. Zouarhi, H. Erramli, N.A. Daoud, N. Badrane, and N. Hajjaji. Chemical composition and antioxidant activity of tannins extract from green rind of Aloe vera (L.) Burm. F. Journal of King Saud UniversityScience 31(4): 1175-1181 (2019).

A. Martínez-Sánchez, M.E. López-Cañavate, J. Guirao-Martínez, M.J. Roca, and E. Aguayo. Aloe vera flowers, a byproduct with great potential and wide application, depending on maturity stage. Foods 9(11): 1542 (2020).

R.B. Yadav, B. Kumar, A. Vats, S.N. Singh, D.P. Pathak, and R. Arora. Development, standardization and validation of analytical method for quality assurance and quality control of Aloe-based pharmaceuticals and nutraceuticals. Trakia Journal of Sciences 4: 294-309 (2020).

S. Ojha, K. Sonker, M. Pandey, and S. Saraf. Aloe vera gel: A potent nutraceutical. Journal of Natural Pharmaceuticals 2(1): 36-36 (2011).

A.Vega-Gálvez, E. Uribe, M. Perez, G. Tabilo-Munizaga, J. Vergara, P. Garcia-Segovia, E. Lara, and K. Di Scala. Effect of high hydrostatic pressure pretreatment on drying kinetics, antioxidant activity, firmness and microstructure of Aloe vera (Aloe barbadensis Miller) gel. LWT-Food Science and Technology 44(2): 384-391 (2011).

S. Lee, S.G. Do, S.Y. Kim, J. Kim, Y. Jin, and C.H. Lee. 2012. Mass spectrometry-based metabolite profiling and antioxidant activity of Aloe vera (Aloe barbadensis Miller) in different growth stages. Journal of Agricultural and Food Chemistry 60(45): 11222-11228.

C. Quispe, M. Villalobos, J. Bórquez, and M. Simirgiotis. Chemical composition and antioxidant activity of Aloe vera from the Pica Oasis (Tarapacá, Chile) by UHPLCQ/Orbitrap/MS/MS. Journal of chemistry 12 pages (2018). Article ID 6123850.

E.H. Kaparakou, C.D. Kanakis, M. Gerogianni, M. Maniati, K. Vekrellis, E. Skotti, and P.A. Tarantilis. Quantitative determination of aloin, antioxidant activity, and toxicity of Aloe vera leaf gel products from Greece. Journal of the Science of Food and Agriculture 101(2): 414-423 (2021).

L.D. Williams, G.A. Burdock, and E. Shin. Safety studies conducted on a proprietary high-purity Aloe vera inner leaf fillet preparation, Qmatrix. Regul Toxicology and Pharmacology 57:90-98 (2010).

A. Devaraj, and T. Karpagam. Evaluation of anti-inflammatory activity and analgesic effect of Aloe vera leaf extract in rats. International Research Journal Pharmacy 2(3): 103-10 (2011).

H.F. Huseini, S. Kianbakht, R. Hajiaghaee, F.H. Dabaghian. Anti-hyperglycemic and antihypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: A randomized double-blind placebocontrolled clinical trial. Planta Medica 78: 311-316 (2012).

D. Vijayalakshmi, R. Dhandapani, S. Jayaveni, P.S. Jithendra, C. Rose, A.B. Mandal. In vitro anti inflammatory activity of Aloe vera by down regulation of MMP-9 in peripheral blood mononuclear cells. Journal of Ethnopharmacology 141(1): 542-546 (2012).

P. Farzadinia, N. Jofreh, S. Khatamsaz, A. Movahed, S. Akbarzadeh, M. Mohammadi, A. Bargahi. Anti-inflammatory and wound healing activities of Aloe vera, honey and milk ointment on second-degree burns in rats. The International Journal of Lower Extremity Wounds 15(3): 241-247 (2016).

M.A. Naini, A. Zargari-Samadnejad, S. Mehrvarz, R. Tanideh, M. Ghorbani, A. Dehghanian, M. Hasanzarrini, F. Banaee, O. Koohi-Hosseinabadi, N. Tanideh, A. Iraji. AntiInflammatory, antioxidant, and healing-promoting effects of Aloe vera extract in the experimental colitis in rats. Evidence-Based Complementary and Alternative Medicine 12 pages (2021). Article ID 9945244.

S. Paul, D. Modak, S. Chattaraj, D. Nandi, A. Sarkar, J. Roy, T.K. Chaudhuri, and S. Bhattacharjee. Aloe vera gel homogenate shows anti-inflammatory activity through lysosomal membrane stabilization and downregulation of TNF-α and Cox-2 gene expressions in inflammatory arthritic animals. Future Journal of Pharmaceutical Sciences 7(1): 1-8 (2021).

J. Jose, S. Sudhakaran, S. Kumar, S. Jayaraman, and E.J. Variyar. A comparative evaluation of anticancer activities of flavonoids isolated from Mimosa pudica, Aloe vera and Phyllanthus niruri against human breast carcinoma cell line (MCF-7) using MTT assay. International Journal of Pharmacy and Pharmaceutical Sciences 6(2): 319-322 (2014).

M. Shalabi, K. Khilo, M.M. Zakaria, M.G. Elsebaei, W. Abdo, and W. Awadin. Anticancer activity of Aloe vera and Calligonum comosum extracts separetely on hepatocellular carcinoma cells. Asian Pacific Journal of Tropical Biomedicine 5(5): 375- 381 (2015).

S.M. López Villarreal, J.H. Elizondo Luévano, R.A. Pérez Hernández, E. Sánchez García, M.J. Verde Star, R. Castro Ríos, M. Garza Tapia, O.E. Rodríguez Luis, and A. Chávez Montes. Preliminary study of the antimicrobial, anticoagulant, antioxidant, cytotoxic, and anti-inflammatory activity of five selected plants with therapeutic application in dentistry. International Journal of Environmental Research and Public Health 19(13): 7927 (2022).

T. Karpagam, J. Firdous, S. Priya, B. Varalakshmi, S. Gomathi, S. Geetha, and N. Muhamad. Anti-cancer activity of aloe vera ethanolic leaves extract against in vitro cancer cells. Research Journal of Pharmacy and Technology 12(5) pp.2167-2170 (2019).

D. Hariharan, P. Thangamuniyandi, A.J. Christy, R. Vasantharaja, P. Selvakumar, S. Sagadevan, A. Pugazhendhi, and L.C. Nehru. Enhanced photocatalysis and anticancer activity of green hydrothermal synthesized Ag@ TiO2 nanoparticles. Journal of Photochemistry and Photobiology B: Biology 202: 111636 (2020).

N. Mohamed, and H.M. El-Masry. Aloe vera gel extract and sunlight mediated synthesis of silver nanoparticles with highly effective antibacterial and anticancer activity. Journal of Nanoanalysis 7(1): 73-82 (2020).

M.P. Murugesan, M.V. Ratnam, Y. Mengitsu, and K. Kandasamy. Evaluation of anti-cancer activity of phytosomes formulated from Aloe vera extract. Materials Today: Proceedings 42: 631-636 (2021).

A. Ahamed, A Panneerselvam, A. Alaklabi, I.A. Arif, V. Ambikapathy, and N. Thajuddin. Molecular perspective and anticancer activity of medicinal plants. Saudi Journal of Biological Sciences 27(2): 666-675 (2020).

A.K. Mohamed. Antidiabetic, antihypercholestermic and antioxidative effect of Aloe vera gel extract in alloxan induced diabetic rats. Australian Journal of Basic and Applied Sciences 5(11): 1321-1327 (2011).

A. Muñiz-Ramirez, R.M. Perez, E. Garcia, and F.E. Garcia. Antidiabetic activity of Aloe vera leaves. Evidence-Based Complementary and Alternative Medicine (2020).

S.N. Babu, S. Govindarajan, and A. Noor. Aloe vera and its two bioactive constituents in alleviation of diabetes–proteomic & mechanistic insights. Journal of Ethnopharmacology 280: p.114445 (2021).

Z.Y.M. Hasan, and J.M. Abdullah. Effects of gel extract from Aloe vera cultivated in Iraq on blood glucose level and lipid profile in induced diabetic mice. Iraqi Journal of Science 2022:124-130 (2022).

S.N. Ankita, and R. Ray. Effectiveness of Aloe vera in patients with diabetes mellitus. The Pharma Innovation Journal 11(2): 1821-1826 (2022).

F. Haghani, M.R. Arabnezhad, S. Mohammadi, and A. Ghaffarian-Bahraman. Aloe vera and Streptozotocin-Induced Diabetes Mellitus. Revista Brasileira de Farmacognosia 2022: 1-14 (2022).

N. Deora, and K. Venkatraman. Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies. Journal of Ayurveda and Integrative Medicine 13(4): 100675 (2022).

I. Amir, D.L. Martino, A. Marandino, H. Lamia, H. Mohsen, and E. Sacndolera. 2013. Chemical composition and biological activities of the essential oil from Artemisia herba-alba growing wild in Tunisia. Natural Product Communication 8: 407-410 (2013). PMID:23678823.

A. Hussain, M. Sajid, H. Rasheed, M. Hassan, M.A. Khan, and S.A.I. Bokhari. Phytochemistry and antibacterial efficacy of Northeastern Pakistani Artemisia rutifolia Stephan ex Spreng. extracts against some clinical and phyto-pathogenic bacterial strains. Acta Pharmaceutica Sciencia 60: 247-271(2022)

M.C. Stanley, O.E. Ifeanyi, and O.G. Eziokwu. Antimicrobial effects of Aloe vera on some human pathogens. International Journal of Current Microbiology and Applied Sciences 3(3): 1022-1028 (2014).

P.N. Waithaka, E.M. Gathuru, B.M. Githaiga, and R.Z. Kazungu. Antimicrobial properties of Aloe vera, Aloe volkensii and Aloe secundiflora from Egerton university. Acta Scientific Microbiology 1(5): 06-10 (2018).

F.I. Gorsi, T. Kausar, and M.A. Murtaza. Evaluation of antibacterial and antioxidant activity of Aloe vera (Aloe barbadensis Miller) gel powder using different solvents. Pure and Applied Biology 8(2): 1265-1270 (2019).

T.R. Anju, S. Parvathy, M.V. Veettil, J. Rosemary, T.H. Ansalna, M.M. Shahzabanu, and S. Devika. Green synthesis of silver nanoparticles from Aloe vera leaf extract and its antimicrobial activity. Materials Today: Proceedings 43: 3956-3960 (2021).

F. Bajalanlou, and B. Pakbin. Chemical properties and sensory evaluation of probiotic yoghurt manufactured with aqueous extract of Aloe vera. Journal of Biology and Today's World 5(11): 197-202 (2016).

T. Ahmed, B. Khedidja, D. Mounir, and C. Salah. Physicochemical and Biological Characteristics of Aloe Barbadensis Miller Gel Extract from Ghardaia, Algeria. In 2nd International Conference on Industry 4.0 and Artificial Intelligence 175: 99-105 (2022).

B. Vadiati Saberi, M. Haddadian, and N. Rasooli. The antibacterial activity of Aloe vera: An invitro study. Journal of Dentomaxillofacial Radiology, Pathology and Surgery 11(2):1 (2022).

R. Yahya, A.M. Al-Rajhi, S.Z. Alzaid, M.A. Al Abboud, M.S. Almuhayawi, S.K. Al Jaouni, S. Selim, K.S. Ismail, and T.M. Abdelghany. Molecular docking and efficacy of Aloe vera gel based on chitosan nanoparticles against Helicobacter pylori and its antioxidant and anti-inflammatory activities. Polymers 14(15): 2994 (2022).

Y. Pounikar, P. Jain, N. Khurana, L.K. Omray, S. Patil, and A. Gajbhiye. Formulation and characterization of Aloe vera cosmetic herbal hydrogel. International Journal of Pharmacy and Pharmaceutical Sciences 4(4): 85-86 (2012).

E. Estrada-Castillón, M. Garza-López, J.A. Villarreal-Quintanilla, M.M. Salinas-Rodríguez, B.E. Soto-Mata, H. González-Rodríguez, D.U. González-Uribe, I. Cantú-Silva, A. Carrillo-Parra, and C. Cantú-Ayala. Ethnobotany in Rayones, Nuevo León, México. Journal of Ethnobiology and Ethnomedicine 10(1), pp.1-13 (2014).

V. Rajkumar, A.K. Verma, G. Patra, S. Pradhan, S. Biswas, P. Chauhan, and A.K. Das. Quality and acceptability of meat nuggets with fresh Aloe vera gel. Asian Australasian Journal of Animal Sciences 29(5): 702-7 (2015).

R. Mahmoudi, F. Bajalanlou, P. Ghajarbeygi, and B. Pakbin. Journal of Biology and Today's World 5(11): 197-202 (2016).

T.Y. Hendrawati, H. Ambarwati, R.A. Nugrahani, S. Susanty, and U.H. Hasyim. The effects of Aloe vera gel addition on the effectiveness of sunscreen lotion. Jurnal Rekayasa Proses 14(1): 116 (2020).

T.Y. Hendrawati, L. Aristio, U.M. Hasyim, R.A. Nugrahani, and A.I. Ramadhan. The effects of adding Aloe chinensis baker gel extract on the formulation of lotion as a cosmetic product. ARPN Journal of Engineering and Applied Sciences 13(23): 9291-9297 (2018).

A.Verma, R. Ansari, and A.A. Broadway. Preparation of herbal ice cream by using Aloe vera with mint flavour. Journal of Pharmacognosy and Phytochemistry 7(3): 391-394 (2018).

S. Kumar, and T. Bhatnagar. Studies to enhance the shelf life of fruits using Aloe vera based herbal coatings: A review. International Journal of Agriculture and Food Science Technology 5(3): 211-218 (2014).

V. Chaudhary, S. Bishnoi, and A. Argade. Development and characterization of Aloe vera juice incorporated burfi. The Pharma Innovation Journal 8(5): 407-411(2019).

S. Masood, A. un Nisa, F. Arif, M. Ashraf, S. Ashraf, H. ur Rehman, S. Hina, I. Ahmad. Aloe vera based cookies as a functional food. Bangladesh Journal of Scientific and Industrial Research 56(4): 293-298 (2021).

K. Mahajan, S. Kumar, Z.F. Bhat, Z. Naqvi, T.E. Mungure, and A.E.D.A. Bekhit. Functionalization of carrageenan based edible film using Aloe vera for improved lipid oxidative and microbial stability of frozen dairy products. Food Bioscience 43: 101336 (2021).

T. Haider, S. Ahmad, M. Abbas, N. Sharif, N. Mahreen, K. Aslam, and A. Noreen. Effect of Aloe vera gel coating on postharvest quality of strawberry fruit (Frageria ananassa). Journal of Agricultural Research. 60(4): 295-303 (2022).

N. Pattnaik, R. Mohanty, A. Satpathy, R. Nayak, R. Shamim, and A.K. Praharaj. Aloe vera mouthwashes can be a natural alternative to chemically formulated ones–A randomized-controlled trial. Journal of Taibah University Medical Sciences 17(3): 424-432 (2022).

M.C. Otálora, A. Wilches-Torres, and J.A. Gómez Castaño. Spray-drying microencapsulation of pink guava (Psidium guajava) carotenoids using mucilage from opuntia ficus-indica cladodes and Aloe vera leaves as encapsulating materials. Polymers 14(2): 310 (2022).



How to Cite

Maira Batool, Malaika Khan, Maria Mubarak, Adil Hussain, Muafia Shafiq, Shamma Firdous, & Asma Saeed. (2023). A Wonder Plant Aloe vera L. (Liliaceae): An Overview of its Folk Traditional Uses, Phytoconstituents, Biological Activities, and Cosmaceutical Applications. Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 60(3). https://doi.org/10.53560/PPASB(60-3)857



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