Homo- and Heteroleptic Cd(II) 4-Phenylbutyrates, Synthesis, Exploration of Chemistry, DNA Binding Study and Antileishmanial Activity
DOI:
https://doi.org/10.53560/PPASA(63-2)717Keywords:
Homo- and Heteroleptic Carboxylates, Chelating Bidentate, Salmon Sperm DNA, Cyclic Voltammetry, Leishmaniasis Tropica Promastigotes, Gelardin’s StrainAbstract
By using 4-phenylbutyric acid (4-PBA) and aromatic nitrogen heterocycles, i.e., 2,2՛-bipyridine (BIPY), 1,10-phenanthroline (PHEN), and 2,9-dimethyl-1,10-phenanthroline (Me2PHEN) as ancillary ligands, four cadmium carboxylates were synthesized. The chemistry and biological applications of the homoleptic complex are discussed under the 4-PB1, whereas the heteroleptic complexes containing BIPY, PHEN, and Me2PHEN are designated as 4-PBB, 4-PBP, and 4-PBD, respectively. Their synthesis and chemistry were explored fully through FT-IR and NMR (1H and 13C) spectroscopy. The FT-IR data in the solid state show the metal coordination with the ligand moieties, where the carboxylate group adopted multi-mode coordination. The absence and presence of resonance signal, along with characteristic multiplicity in the solution 1H as well as 13C NMR data, confirm targeted synthesis. The assessment of the synthesized complexes for their binding ability with DNA was executed through multiple techniques, including UV-Vis absorption spectroscopy, viscometry, and cyclic voltammetry. The findings from all techniques support that the complexes interact with DNA through a dual mode of binding following a smooth process. The complex having an attached phenanthroline was found to be active in all attributed to its increased planar area and availability of bonding interactions. The antileishmanial study reveals that the synthesized complexes exhibit good to moderate activity against the amastigotes of L. tropica as compared to the standard drug used in the study.
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