Comparative Analgesic Activity of Selected Medicinal Plants from Pakistan

Analgesics from plants

Authors

  • Huma Shareef Department of Pharmacognosy, Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi
  • Sadaf Naeem Department of Pharmacy, Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi
  • Erum Zaheer Department of Pharmaceutical chemistry, Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi

Keywords:

Analgesics, Medicinal plants, Non-steroidal anti-inflammatory (NSAIDs), Pain, Phytochemicals, Side effects

Abstract

Pain is a natural self-protective system which is always unpleasant both mentally and physically with probable tissue harm. Analgesics are the medicinal agents which relief the pain without losing consciousness. Medicinal plants are being widely used all over the world for human healthy life form. We selected ten Pakistani plants which play an important role as traditional medicine in the prevention and management of acute and chronic diseases. All plants were extracted with ethanol and have been investigated for analgesic effects using hotplate and writhing reflex tests in rats. Phytochemical screening revealed the presence of polyphenols, saponins, sugar, flavonoids, and alkaloid. In our research, the analgesic effect of selected medicinal plants shows significant effect like standard aspirin and diclophenic. The intake of these aforementioned phytochemical flavonoids and polyphenols are considered to be responsible for pain management because they may contain many powerful antioxidant and free radical scavenging capabilities which are the backbone of other bioactivities such as anti-inflammatory action, anticancer, anti-aging, and protective action for cardiovascular diseases, diabetes mellitus, obesity and neurodegenerative disorders. In future, these plants may be utilized as a health benefit in view of their potential research in the prevention and management of pain.

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Published

2019-09-19

How to Cite

Shareef, H. ., Naeem, S. ., & Zaheer, E. . (2019). Comparative Analgesic Activity of Selected Medicinal Plants from Pakistan: Analgesics from plants. Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 56(3), 57–67. Retrieved from http://ppaspk.org/index.php/PPAS-B/article/view/111

Issue

Vol. 56 No. 3 (2019): Special Issue

Section

Research Articles

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