Endophytes: Potential Source of Bioactive Compounds of Pharmaceutical Importance

Pharmaceutical Importance of Bioactive Compounds from Endophytes


  • Tahira Younis Department of Plant Sciences, Quaid-i-Azam University, Islamabad
  • Lubna Rahman Department of Biotechnology, Quaid-i-Azam University, Islamabad
  • Sidra Rahman Department of Biotechnology, Quaid-i-Azam University, Islamabad
  • Afnan Khan Shinwari Department of Plant Sciences, Quaid-i-Azam University, Islamabad
  • Irum Iqrar Pakistan Academy of Sciences, Islamabad
  • Zabta Khan Shinwari Department of Plant Sciences, Quaid-i-Azam University, Islamabad




Endophytes, Antibiotics, Antimicrobial, Medicinal Plants, Secondary Metabolites, Pharmacology


Microbes exist as mutualists, parasites, and symbionts or as pathogens in nature. In plant microbiota, plant immunity determines whether the interaction with microbes is friendly or hostile. Friendly interaction may have an eccentric way of mutual interrelations for a resource contribution. This interaction is called plant-endophyte mutualistic or symbiotic relation in which microorganisms (fungi, bacteria, and actinomycetes) live within robust plant tissues. It has been discovered that almost all plant species investigated by various researchers harbor one or more endophytes. They benefit their host by producing various secondary metabolites that can be employed in agriculture and medicine. Endophytes are a treasure house of many novel bioactive compounds such as steroids, tannins, terpenoids, quinones, alkaloids, saponins, and phenolic acids which makes them a potential candidate for anticancer, antibiotic, antioxidant, anti-inflammatory, antiviral, antidiabetic properties, etc. Endophytes continue to be the peculiar source of various potential drugs. This review intends to shed light on the function and potential applications of endophytes as a forthcoming source of medications for a range of illnesses/diseases as well as other potential medical uses.


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How to Cite

Tahira Younis, Rahman, L., Rahman, S., Shinwari, A. K., Irum Iqrar, & Zabta Khan Shinwari. (2022). Endophytes: Potential Source of Bioactive Compounds of Pharmaceutical Importance: Pharmaceutical Importance of Bioactive Compounds from Endophytes. Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 59(4), 1–13. https://doi.org/10.53560/PPASB(59-4)780