Stability Analysis of Sorensen's Model for Controllability and Observability
Stability Analysis of Sorensen’s Model
Keywords:
Glucose, Insulin, Glucagon, controllability, observability, Sorenson’s modelAbstract
Stability analysis of a model of glucose insulin glucagon system in humans is made which is one of the important factors for study of model for healthy life. If glucose, insulin or glucagon is negative then it will not be stable and cannot be treated for controllability or observability. Sorenson’s Model is used for this purpose because it is most comprehensive model for glucose, insulin and glucagon in humans. Equilibrium points for different case of concentration of glucose are calculated for stability of the system. Results are refined by using fsolve and fminsearch techniques in Matlab which turn out to be negative value of labile Insulin for all cases and techniques. In this situation we will be unable to find the control of the system in this model
References
Murray, J.D. Mathematical Biology. I. An Introduction. Springer Verlag, Berlin (2002).
Farman, M. M.U. Saleem, & A. Meraj. Control of Glucose insulin regulatory system for type 1 diabetes.
Science International (Lahore) 28: 19-24 (2016).
Sorensen, J.T. A Physiological Model of Glucose Metabolism in Man and Its Use to Design and Assess
Improved Insulin Therapies for Diabetes. PhD thesis, Massachusetts Institute of Technology, Cambridge,
Massachusetts, USA (1985).
Saleem, M.U., M. Farman, & A. Meraj. A linear control of Hovorka model. Science International (Lahore) 28:
-18 (2016).
G. Quiroz, & R. Femat, On Hyperglycemic Glucose Basal Levels in Type 1 DiabetesMellitus from Dynamic Analysis, Mathematical Biosciences. 210(2) 554-575(2007).
Saleem, M.U. Controllability and Observability in Glucose Insulin System in Human. PhD thesis, KarlFranzens University, Graz, Austria. (2011).
Wiam, B. A mathematical model of glucose, insulin, B-cells, A-cells and glucagon. BAOJ Diabetes 1:1. 1:001 (2015).
Downloads
Published
How to Cite
Issue
Section
License
Creative Commons Attribution (CC BY). Allows users to: copy the article and distribute; abstracts, create extracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation); include in a collective work (such as an anthology); and text or data mine the article. These uses are permitted even for commercial purposes, provided the user: includes a link to the license; indicates if changes were made; gives appropriate credit to the author(s) (with a link to the formal publication through the relevant DOI); and does not represent the author(s) as endorsing the adaptation of the article or modify the article in such a way as to damage the authors' honor or reputation.