Implementing GRADE-ADOLOPMENT for Clinical Practice Guidelines in Resource-Limited Settings: The AKU Experience

Implementing GRADE-ADOLOPMENT for Clinical Practice Guidelines

Authors

  • Ainan Arshad Department of Medicine, Aga Khan University, Karachi, Pakistan
  • Muhammad Hamayl Zeeshan Centre for Clinical Best Practices, Aga Khan University, Karachi, Pakistan
  • Mohsin Ali Mustafa Centre for Clinical Best Practices, Aga Khan University, Karachi, Pakistan
  • Nashia Rizvi Centre for Clinical Best Practices, Aga Khan University, Karachi, Pakistan
  • Alina Abdul Rehman Centre for Clinical Best Practices, Aga Khan University, Karachi, Pakistan
  • Alina Pervez Centre for Clinical Best Practices, Aga Khan University, Karachi, Pakistan
  • Adil H. Haider Medical College, Aga Khan University, Karachi, Pakistan

DOI:

https://doi.org/10.53560/PPASB(61-sp1)1009

Keywords:

Adaptation, Clinical Practice Guidelines, De-novo guidelines, Evidence-to-Decision tables, GRADE-ADOLOPMENT

Abstract

In regions grappling with limited resources to support the formulation of evidence-based Clinical Practice Guidelines (CPGs), GRADE-ADOLOPMENT offers a unique pathway to craft guidelines tailored to the specific needs of areas with sparse CPGs. The Aga Khan University in Karachi, Pakistan, used GRADE-ADOLOPMENT to create guidelines for prevalent diseases in Pakistan. An adaptation of the GRADE-ADOLOPMENT methodology was employed in collaboration with the US GRADE working group. ADOLOPMENT is a combination of de-novo creation, adoption (use as is or with minor changes), or adaptation (modification based on local context) of recommendations. After the selection of a source guideline (SG), the recommendations were either adopted, adapted, or excluded. Adaptations were done using the Evidence-To-Decision table. Contextualized CPGs were developed for Pakistan, covering over 25 medical specialties. The article discusses the wide variety of topics and specialties covered using GRADE-ADOLOPMENT in Pakistan for the first time. The lessons learned from this resource-constrained GRADEADOLOPMENT experience provide valuable guidance for teams undertaking projects in similar resource-limited settings. The GRADE-ADOLOPMENT experience at AKU in Pakistan serves as a valuable example, showcasing both the challenges and creative solutions in the context of medical guideline development in resource-limited regions.

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Published

2024-04-24

How to Cite

Ainan Arshad, Muhammad Hamayl Zeeshan, Mohsin Ali Mustafa, Nashia Rizvi, Alina Abdul Rehman, Alina Pervez, & Adil H. Haider. (2024). Implementing GRADE-ADOLOPMENT for Clinical Practice Guidelines in Resource-Limited Settings: The AKU Experience : Implementing GRADE-ADOLOPMENT for Clinical Practice Guidelines. Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 61(S). https://doi.org/10.53560/PPASB(61-sp1)1009

Issue

Vol. 61 No. S (2024): Special Issue on Pathogen Transmission Beyond Borders: Understanding the Complexities of Cross-species Infectious Diseases

Section

Research Articles

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