Contemporary Strategies for Managing and Controlling Viral Outbreaks: An Overview

Contemporary Strategies for Managing and Controlling Viral Outbreaks

Authors

  • Mohammad Ejaz Department of Microbiology, Government Postgraduate College Mandian, Abbottabad, Pakistan
  • Muhammad Ali Syed Department of Microbiology, The University of Haripur, Haripur, Pakistan
  • Rani Faryal Department of Microbiology, Quaid-i-Azam University, Islamabad, Pakistan
  • Sheryar Jamil Department of Microbiology, Government Postgraduate College Mandian, Abbottabad, Pakistan

DOI:

https://doi.org/10.53560/PPASB(61-sp1)1004

Keywords:

Blood-borne viruses, Epidemic, Pandemic, Respiratory viruses, Vector-borne viruses, Viral outbreaks

Abstract

Viruses are notorious for causing a significant array of infectious diseases, rendering them a prominent contributor to global morbidity and mortality rates. Throughout history, various regions have experienced outbreaks, epidemics, and pandemics, resulting in significant mortality rates. The Influenza virus gave rise to highly fatal outbreaks that disseminated on a global scale, subsequently resulting in a pandemic during the initial decades of the 20th century. This catastrophic event led to >75 million fatalities, accompanied by a substantial incidence of illnesses. In addition to the development of efficacious treatments for viral diseases, it is imperative to establish and implement various preventive measures to mitigate the transmission of diseases within both local and global populations. Furthermore, it is critical to implement proven conventional and contemporary strategies for managing viral infections, alongside bolstered surveillance systems. Viruses employ diverse modes of transmission, encompassing respiratory, oral-fecal, blood-borne, and vector-borne pathways. Consequently, effective measures to mitigate viral dissemination must be tailored to address each distinct route of transmission. This review discusses the existing strategies employed to mitigate the transmission and containment of viral outbreaks, as well as the dissemination of the disease within a sizable population, intending to reduce their detrimental and fatal impacts on a community.

References

J.D. Chappell, and T.S. Dermody. Biology of viruses and viral diseases. Mandell, Douglas, and Bennett's

Principles and Practice of Infectious Diseases: 1681 (2015).

ICTV. Virus Taxonomy: 2020 Release. (2022) https://talk.ictvonline.org/taxonomy/. (accessed 22 Aug 2022)

A. Wilder-Smith, and S. Osman. Public health emergencies of international concern: a historic overview. Journal

of Travel Medicine 27: taaa227 (2020).

N. Madhav, B. Oppenheim, M. Gallivan, P. Mulembakani, E. Rubin and N. Wolfe. Pandemics: risks, impacts, and

mitigation. (2018).

M. Porta. A dictionary of epidemiology. Oxford University Press (2014).

S. Drosten, S. Günther, W. Preiser, S. Van Der Werf, H.R. Brodt, and S. Becker. Identification of a novel

coronavirus in patients with severe acute respiratory syndrome. New England journal of medicine 348: 1967-1976

(2003).

A.M. Zaki, S. Van Boheemen, T.M. Bestebroer, A.D. Osterhaus, and R.A. Fouchier. Isolation of a novel

coronavirus from a man with pneumonia in Saudi Arabia. New England Journal of Medicine 367: 1814-1820

(2012).

G.J. Smith, D. Vijaykrishna, J. Bahl, S.J. Lycett, M. Worobey, and O.G. Pybus. Origins and evolutionary

genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459: 1122-1125 (2009).

E.C. Holmes, G. Dudas, A. Rambaut and K.G. Andersen. The evolution of Ebola virus: Insights from the

–2016 epidemic. Nature 538: 193-200 (2016).

N.D. Grubaugh, N.R. Faria, K.G. Andersen, and O.G. Pybus. Genomic insights into Zika virus emergence and

spread. Cell 172: 1160-1162 (2018).

S. Riedel. Edward Jenner and the history of smallpox and vaccination. in Baylor University Medical Center

Proceedings. Taylor & Francis (2005).

I.H. Hussein, N. Chams, S. Chams, S. El Sayegh, R. Badran, and M. Raad. Vaccines through centuries: major

cornerstones of global health. Frontiers in Public Health 3: 269 (2015).

P. Bhadoria, G. Gupta, and A. Agarwal. Viral pandemics in the past two decades: an overview. Journal of family

medicine and primary care 10: 2745 (2021).

S. Roychoudhury, A. Das, P. Sengupta, S. Dutta, S. Roychoudhury, and A.P. Choudhury. Viral pandemics of the

last four decades: pathophysiology, health impacts, and perspectives. International Journal of Environmental

Research and Public Health 17: 9411 (2020).

N.D. Grubaugh, J.T. Ladner, P. Lemey, O.G. Pybus, A. Rambaut, and E.C. Holmes. Tracking virus outbreaks in

the twenty-first century. Nature Microbiology 4: 10-19 (2019).

R.M. Meganck, R.M., and R.S. Baric. Developing therapeutic approaches for twenty-first-century emerging

infectious viral diseases. Nature Medicine 27: 401-410 (2021).

N.D. Wolfe, C.P. Dunavan, and J. Diamond. Origins of major human infectious diseases. Nature 447: 279-283

(2007).

J.J. Dennehy. Evolutionary ecology of virus emergence. Annals of the New York Academy of Sciences 1389: 124-

(2017).

J.A. Blanchong, S.J. Robinson, M.D. Samuel, and J.T. Foster. Application of genetics and genomics to wildlife

epidemiology. The Journal of Wildlife Management 80: 593-608 (2016).

E.C. Holmes, A. Rambaut, and K.G. Andersen. Pandemics: spend on surveillance, not prediction. Nature

Publishing Group (2018).

W.B. Karesh, A. Dobson, J.O. Lloyd-Smith, J. Lubroth, M.A. Dixon, and M. Bennett. Ecology of zoonoses:

natural and unnatural histories. The Lancet 380: 1936-1945 (2012).

N.I. Nii‐Trebi, T.S. Mughogho, A. Abdulai, F. Tetteh, P.M. Ofosu, and M.M. Osei. Dynamics of viral disease

outbreaks: A hundred years (1918/19–2019/20) in retrospect‐Loses, lessons and emerging issues. Reviews in

Medical Virology 33: e2475 (2023).

W.J. Alonso, B.J. Laranjeira, S.A. Pereira, C.M. Florencio, E.C. Moreno, and M.A. Miller. Comparative

dynamics, morbidity and mortality burden of pediatric viral respiratory infections in an equatorial city. The

Pediatric Infectious Disease Journal 31: e9 (2012).

J.S. Kutter, M.I. Spronken, P.L. Fraaij, R.A. Fouchier, and S. Herfst. Transmission routes of respiratory viruses

among humans. Current opinion in virology 28: 142-151 (2018).

A.C. Lowen, and J. Steel. Roles of humidity and temperature in shaping influenza seasonality. Journal of

Virology 88: 7692-7695 (2014).

O. Ruuskanen, E. Lahti, L.C. Jennings, and D.R. Murdoch. Viral pneumonia. The Lancet 377: 1264-1275 (2011).

W.H. Organization. Surveillance strategies for COVID-19 human infection: interim guidance, 10 May 2020.

World Health Organization (2020)

T.M. Uyeki, J.M. Katz, and D.B. Jernigan. Novel influenza A viruses and pandemic threats. The Lancet 389:

-2174 (2017).

A.A Rabaan, S.H. Al-Ahmed, S. Haque, R. Sah, R. Tiwari, and Y.S. Malik. SARS-CoV-2, SARS-CoV, and

MERS-COV: a comparative overview. Infez Med 28: 174-184 (2020).

J.A. Al-Tawfiq, A. Zumla, P. Gautret, G.C. Gray, D.S. Hui, and A.A. Al-Rabeeah. Surveillance for emerging

respiratory viruses. The Lancet Infectious Diseases 14: 992-1000 (2014).

S.S Morse. Public health disease surveillance networks. One Health: People, Animals, and the Environment: 195-

(2014).

A.Topirceanu, M. Udrescu, and R. Marculescu. Centralized and decentralized isolation strategies and their impact

on the COVID-19 pandemic dynamics. arXiv preprint arXiv:2004.04222: (2020).

C. Wilasang, C. Sararat, N.C. Jitsuk, N. Yolai, P. Thammawijaya, and P. Auewarakul. Reduction in effective

reproduction number of COVID-19 is higher in countries employing active case detection with prompt isolation.

Journal of Travel Medicine 27: taaa095 (2020).

T. Zhao, C. Cheng, H. Liu, and C. Sun. Is one-or two-meters social distancing enough for COVID-19? Evidence

for reassessing. Public Health 185: 87 (2020).

C. Jenkins, and A. Sunjaya. Social distancing as a strategy to prevent respiratory virus infections. Respirology 26:

-144 (2021).

H. Khataee, I. Scheuring, A. Czirok, and Z. Neufeld. Effects of social distancing on the spreading of COVID-19

inferred from mobile phone data. Scientific Reports 11: 1-9 (2021).

M.E. Kretzschmar, G. Rozhnova, and M. van Boven. Isolation and contact tracing can tip the scale to containment

of COVID-19 in populations with social distancing. Frontiers in Physics 8: 677 (2021).

S. La Maestra, A. Abbondandolo, and S. De Flora. Epidemiological trends of COVID‐19 epidemic in Italy over

March 2020: From 1000 to 100 000 cases. Journal of Medical Virology 92: 1956-1961 (2020).

K. Prem, Y. Liu, T.W. Russell, A.J. Kucharski, R.M. Eggo, and N. Davies. The effect of control strategies to

reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study. The Lancet

Public Health 5: e261-e270 (2020).

A. Alborzi, M.H. Aelami, M. Ziyaeyan, M. Jamalidoust, M. Moeini, and B. Pourabbas. Viral etiology of acute

respiratory infections among Iranian Hajj pilgrims, 2006. Journal of Travel Medicine 16: 239-242 (2009).

CDC. Handwashing: Clean Hands Save Lives. (2020) https://www.cdc.gov/handwashing/index.html (accessed

Jan 2020).

G.P. Dolan, R.C. Harris, M. Clarkson, R. Sokal, G. Morgan, and M. Mukaigawara. Vaccination of health care

workers to protect patients at increased risk for acute respiratory disease. Emerging infectious diseases 18: 1225

(2012).

J. Horcajada, T. Pumarola, J. Martinez, G. Tapias, J. Bayas, and M. De la Prada. A nosocomial outbreak of

influenza during a period without influenza epidemic activity. European Respiratory Journal 21: 303-307 (2003).

R. Barranco, L. Vallega Bernucci Du Tremoul, and F. Ventura. Hospital-acquired SARS-Cov-2 infections in

patients: inevitable conditions or medical malpractice? International Journal of Environmental Research and

Public Health 18: 489 (2021).

V. Schwierzeck, J.C. König, J. Kühn, A. Mellmann, C.L. Correa-Martínez, and H. Omran. First Reported

Nosocomial Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Dialysis Unit. Clinical

Infectious Diseases 72: 265-270 (2021).

S. Plotkin. History of vaccination. Proceedings of the National Academy of Sciences 111: 12283-12287 (2014).

WHO. Types of seasonal influenza vaccine. (2020) https://www.euro.who.int/en/health-topics/communicable-

diseases/influenza/vaccination/types-of-seasonal-influenza

vaccine#:~:text=Two%20types%20of%20influenza%20vaccine,(also%20called%20trivalent%20vaccines).

(accessed 12 Nov 2020).

C.S. Ambrose, and M.J. Levin. The rationale for quadrivalent influenza vaccines. Human vaccines &

immunotherapeutics 8: 81-88 (2012).

S. Gouma, E.M. Anderson, and S.E. Hensley. Challenges of making effective influenza vaccines. Annual review

of virology 7: 495-512 (2020).

M. Shafique, M.A. Zahoor, M.I. Arshad, B. Aslam, A.B. Siddique, and M.H. Rasool. Hurdles in Vaccine

Development against Respiratory Syncytial Virus, in The Burden of Respiratory Syncytial Virus Infection in the

Young. IntechOpenpp. (2019).

S. Lee, M.T. Nguyen, M.G. Currier, J.B. Jenkins, E.A. Strobert, and A.E. Kajon. A polyvalent inactivated

rhinovirus vaccine is broadly immunogenic in rhesus macaques. Nature Communications 7: 1-7 (2016).

T. Zohar, J.C. Hsiao, N. Mehta, J. Das, A. Devadhasan, and W. Karpinski. Upper and lower respiratory tract

correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates. Cell host

& microbe: (2021).

A. Killikelly, M. Tunis, A. House, C. Quach, W. Vaudry, and D. Moore. Respiratory syncytial virus: Overview of

the respiratory syncytial virus vaccine candidate pipeline in Canada. Canada Communicable Disease Report 46:

(2020).

H. Le Calvez, M. Yu, and F. Fang. Biochemical prevention and treatment of viral infections–A new paradigm in

medicine for infectious diseases. Virology Journal 1: 12 (2004).

A. Rocca, C. Biagi, S. Scarpini, A. Dondi, S. Vandini, and L. Pierantoni. Passive Immunoprophylaxis against

Respiratory Syncytial Virus in Children: Where Are We Now? International Journal of Molecular Sciences 22:

(2021).

S. Mac, A. Sumner, S. Duchesne-Belanger, R. Stirling, M. Tunis, and B. Sander. Cost-effectiveness of

palivizumab for respiratory syncytial virus: a systematic review. Pediatrics 143: (2019).

E. Bizot, A. Bousquet, M. Charpié, F. Coquelin, S. Lefevre, and J. Le Lorier. Rhinovirus: A Narrative Review on

Its Genetic Characteristics, Pediatric Clinical Presentations, and Pathogenesis. Frontiers in Pediatrics 9: 113

(2021).

R.L. Gottlieb, A. Nirula, P. Chen, J. Boscia, B. Heller, and J. Morris. Effect of bamlanivimab as monotherapy or

in combination with etesevimab on viral load in patients with mild to moderate COVID-19: a randomized clinical

trial. Jama 325: 632-644 (2021).

J.A. Englund. Antiviral therapy of influenza. in Seminars in pediatric infectious diseases. 2002. Elsevier.

CDC. Influenza vaccines — United States, 2020–21 influenza season. (2021)

https://www.cdc.gov/flu/professionals/acip/2020-2021/acip-table.htm (accessed 26 Jan 2021).

V. Gresset-Bourgeois, P.S. Leventhal, S. Pepin, R. Hollingsworth, M.P. Kazek-Duret, and I. De Bruijn.

Quadrivalent inactivated influenza vaccine (VaxigripTetra™). Expert review of vaccines 17: 1-11 (2018).

L.D. Saravolatz, K.M. Empey, R.S. Peebles Jr, and J.K. Kolls. Pharmacologic advances in the treatment and

prevention of respiratory syncytial virus. Clinical Infectious Diseases 50: 1258-1267 (2010).

J. Hendriks, and S. Blume. Measles vaccination before the measles-mumps-rubella vaccine. American journal of

public health 103: 1393-1401 (2013).

A. Bichon, C. Aubry, L. Benarous, H. Drouet, C. Zandotti, and P. Parola. Case report: Ribavirin and vitamin A in

a severe case of measles. Medicine 96: (2017).

S. Gouma, I. Hinke, T.M. Schurink-van’t Klooster, H.E. de Melker, G.J. Boland, and P. Kaaijk. Mumps-specific

cross-neutralization by MMR vaccine-induced antibodies predicts protection against mumps virus infection.

Vaccine 34: 4166-4171 (2016).

U. Sandkovsky, L. Vargas, and D.F. Florescu. Adenovirus: current epidemiology and emerging approaches to

prevention and treatment. Current infectious disease reports 16: 416 (2014).

C.H. Hoke Jr, and C.E. Snyder Jr. History of the restoration of adenovirus type 4 and type 7 vaccine, live oral

(Adenovirus Vaccine) in the context of the Department of Defense acquisition system. Vaccine 31: 1623-1632

(2013).

A. Anzueto, and M.S. Niederman. Diagnosis and treatment of rhinovirus respiratory infections. Chest 123: 1664-

(2003).

J.H. Beigel, K.M. Tomashek, L.E. Dodd, A.K. Mehta, B.S. Zingman, and A.C. Kalil. Remdesivir for the

treatment of Covid-19—preliminary report. The New England journal of medicine: (2020).

R.C. Group. Dexamethasone in hospitalized patients with Covid-19—preliminary report. New England Journal of

Medicine: (2020).

CDC. Different COVID-19 Vaccines. (2020) https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-

vaccines.html (accessed 2 Feb 2020).

T.H. Tulchinsky. John Snow, Cholera, the broad street pump; waterborne diseases then and now. Case Studies in

Public Health: 77 (2018).

R. Bonita, R. Beaglehole, and T. Kjellström, Basic epidemiology. World Health Organization (2006).

M. Kosek, C. Bern, and R.L. Guerrant. The global burden of diarrhoeal disease, as estimated from studies

published between 1992 and 2000. Bulletin of the World Health Organization 81: 197-204 (2003).

P.H. Dennehy. Effects of vaccine on rotavirus disease in the pediatric population. Current opinion in pediatrics

: 76-84 (2012).

T. Vesikari. Norovirus Vaccines in Pipeline Development, in Pediatric Vaccines and Vaccinations. Springerpp.

-292 (2021).

M.A. Widdowson, E.H. Cramer, L. Hadley, J.S. Bresee, R.S. Beard, and S.N. Bulens. Outbreaks of acute

gastroenteritis on cruise ships and on land: identification of a predominant circulating strain of norovirus—United

States, 2002. The Journal of Infectious Diseases 190: 27-36 (2004).

J. Xerry, C.I. Gallimore, M. Iturriza-Gómara, D.J. Allen, and J.J. Gray. Transmission events within outbreaks of

gastroenteritis determined through analysis of nucleotide sequences of the P2 domain of genogroup II

noroviruses. Journal of Clinical Microbiology 46: 947-953 (2008).

L. Baert, M. Uyttendaele, A. Stals, E. Van Coillie, K. Dierick, and J. Debevere. Reported foodborne outbreaks

due to noroviruses in Belgium: the link between food and patient investigations in an international context.

Epidemiology & Infection 137: 316-325 (2009).

G. Belliot, A. Lavaux, D. Souihel, D. Agnello, and P. Pothier. Use of murine norovirus as a surrogate to evaluate

resistance of human norovirus to disinfectants. Applied and environmental microbiology 74: 3315-3318 (2008).

I. Barrabeig, A. Rovira, J. Buesa, R. Bartolomé, R. Pintó, H. Prellezo, and À. Domínguez. Foodborne norovirus

outbreak: the role of an asymptomatic food handler. BMC Infectious Diseases 10: 1-7 (2010).

M. Romão, A. Didier, and A. Brandes. www. cdc. gov/eid. Emerging Infectious Diseases: 1310 (2011).

M. O’Ryan, Y. Lucero, and A.C. Linhares. Rotarix®: vaccine performance 6 years postlicensure. Expert review

of vaccines 10: 1645-1659 (2011).

S. La Frazia, A. Ciucci, F. Arnoldi, M. Coira, P. Gianferretti, and M. Angelini. Thiazolides, a new class of

antiviral agents effective against rotavirus infection, target viral morphogenesis, inhibiting viroplasm formation.

Journal of Virology 87: 11096-11106 (2013).

J.M. Hyser, and M.K. Estes. Rotavirus vaccines and pathogenesis: 2008. Current Opinion in Gastroenterology

: 36 (2009).

J. Kocher, and L. Yuan. Norovirus vaccines and potential antinorovirus drugs: recent advances and future

perspectives. Future Virology 10: 899-913 (2015).

C. Bravo, L. Mege, C. Vigne, and Y. Thollot. Clinical experience with the inactivated hepatitis A vaccine,

Avaxim 80U Pediatric. Expert Review of Vaccines 18: 209-223 (2019).

K. Van Herck, G. Leroux-Roels, P. Van Damme, K. Srinivasa, and B. Hoet. Ten-year antibody persistence

induced by hepatitis A and B vaccine (Twinrix™) in adults. Travel medicine and infectious disease 5: 171-175

(2007).

E. Ehrenfeld, J. Modlin, and K. Chumakov. Future of polio vaccines. Expert review of vaccines 8: 899-905

(2009).

L. Prescott, J. Harley, and D. Klein. Microbiology. 5th. McGraw Hil1: (2002).

F. Gobbi, L. Barzon, G. Capelli, A. Angheben, M. Pacenti, and G. Napoletano. Surveillance for West Nile,

dengue, and chikungunya virus infections, Veneto Region, Italy, 2010. Emerging Infectious Diseases 18: 671

(2012).

B. Dietzschold, J. Li, M. Faber, and M. Schnell. Concepts in the pathogenesis of rabies. (2008).

O. Ergönül. Crimean-Congo haemorrhagic fever. The Lancet Infectious Diseases 6: 203-214 (2006).

V. Sikka, V.K. Chattu, R.K. Popli, S.C. Galwankar, D. Kelkar, and S.G. Sawicki. The emergence of Zika virus as

a global health security threat: a review and a consensus statement of the INDUSEM Joint Working Group

(JWG). Journal of Global Infectious Diseases 8: 3 (2016).

WHO. How to Avoid vector-Borne diseases – top tips. (2014) https://www.who.int/westernpacific/about/how-we-

work/pacific-support/news/detail/07-04-2014-world-health-day-2014-preventing-vector-borne-diseases (accessed

Nov 2020).

H. van den Berg, M. Zaim, R.S. Yadav, A. Soares, B. Ameneshewa, A. Mnzava, J. Hii, A.P. Dash, and M. Ejov.

Global trends in the use of insecticides to control vector-borne diseases. Environmental Health Perspectives 120:

-582 (2012).

S.D. Rodriguez, H.-N. Chung, K.K. Gonzales, J. Vulcan, Y. Li, and J.A. Ahumada. Efficacy of some wearable

devices compared with spray-on insect repellents for the yellow fever mosquito, Aedes aegypti (L.)(Diptera:

Culicidae). Journal of Insect Science 17: 24 (2017).

I. Unlu, D.S. Suman, Y. Wang, K. Klingler, A. Faraji, and R. Gaugler. Effectiveness of autodissemination stations

containing pyriproxyfen in reducing immature Aedes albopictus populations. Parasites & vectors 10: 1-10 (2017).

S.A. Ritchie, G.J. Devine, G.M. Vazquez-Prokopec, A.E. Lenhart, P. Manrique-Saide, and T.W. Scott,

Insecticide-based approaches for dengue vector control, in Ecology and Control of Vector-Borne Diseases.

Wageningen Academic Publisherspp. 380-390 (2021).

Z.H. Amelia-Yap, C.D. Chen, M. Sofian-Azirun, and V.L. Low. Pyrethroid resistance in the dengue vector Aedes

aegypti in Southeast Asia: present situation and prospects for management. Parasites & Vectors 11: 1-17 (2018).

N.L. Achee, M.J. Bangs, R. Farlow, G.F. Killeen, S. Lindsay, J.G. Logan, S.J. Moore, M. Rowland, K. Sweeney,

S.J. Torr, and L.J. Zwiebel. Spatial repellents: from discovery and development to evidence-based validation.

Malaria Journal 11: 1-9 (2012).

N.L. Achee, J.P. Grieco, H. Vatandoost, G. Seixas, J. Pinto, and L. Ching-Ng. Alternative strategies for mosquito-

borne arbovirus control. PLoS Neglected Tropical Diseases 13: e0006822 (2019).

T. Glare, and M. O’Callaghan. Bacillus thuringiensis: Biology, Ecology and Safety. John Wiley & Sons. Inc.,

New York, NY: (2000).

X. Zheng, D. Zhang, Y. Li, C. Yang, Y. Wu, and X. Liang. Incompatible and sterile insect techniques combined

eliminate mosquitoes. Nature 572: 56-61 (2019).

R.S. Lees, J.R. Gilles, J. Hendrichs, M.J. Vreysen, and K. Bourtzis. Back to the future: the sterile insect technique

against mosquito disease vectors. Current Opinion in Insect Science 10: 156-162 (2015).

B. Durovni, V. Saraceni, A. Eppinghaus, T.I. Riback, L.A. Moreira, and N.P. Jewell. The impact of large-scale

deployment of Wolbachia mosquitoes on dengue and other Aedes-borne diseases in Rio de Janeiro and Niterói,

Brazil: study protocol for a controlled interrupted time series analysis using routine disease surveillance data.

F1000Research 8: (2019).

S.B. Pinto, T.I. Riback, G. Sylvestre, G. Costa, J. Peixoto, and F.B. Dias. Effectiveness of Wolbachia-infected

mosquito deployments in reducing the incidence of dengue and other Aedes-borne diseases in Niterói, Brazil: A

quasi-experimental study. PLoS Neglected Tropical Diseases 15: e0009556 (2021).

S. Haq, R. Yadav, and V. Kohli. Developing larvivorous fish network for mosquito control in urban areas: A case

study. ICMR Bull 33: 69-73 (2003).

R. Bellini, H. Zeller, and W. Van Bortel. A review of the vector management methods to prevent and control

outbreaks of West Nile virus infection and the challenge for Europe. Parasites & Vectors 7: 1-11 (2014).

J.M. Darbro, and M.B. Thomas. Spore persistence and likelihood of aeroallergenicity of entomopathogenic fungi

used for mosquito control. The American Journal of Tropical Medicine and Hygiene 80: 992-997 (2009).

S. Flasche, M. Jit, I. Rodríguez-Barraquer, L. Coudeville, M. Recker, and K. Koelle. The long-term safety, public

health impact, and cost-effectiveness of routine vaccination with a recombinant, live-attenuated dengue vaccine

(Dengvaxia): a model comparison study. PLoS Medicine 13: e1002181 (2016).

T.D. Querec, R.S. Akondy, E.K. Lee, W. Cao, H.I. Nakaya, and D. Teuwen. Systems biology approach predicts

immunogenicity of the yellow fever vaccine in humans. Nature Immunology 10: 116-125 (2009).

R. Ghildiyal, and R. Gabrani. Antiviral therapeutics for chikungunya virus. Expert Opinion on Therapeutic

Patents 30: 467-480 (2020).

A.C. Sayce, J.L. Miller, and N. Zitzmann. Glucocorticosteroids as dengue therapeutics: resolving clinical

observations with a primary human macrophage model. Clinical Infectious Diseases 56: 901-903 (2013).

Y.S. Tian, Y. Zhou, T. Takagi, M. Kameoka, and N. Kawashita. Dengue virus and its inhibitors: a brief review.

Chemical and Pharmaceutical Bulletin 66: 191-206 (2018).

E. Escribano-Romero, N.J. de Oya, E. Domingo, and J.C. Saiz. Extinction of West Nile virus by favipiravir

through lethal mutagenesis. Antimicrobial agents and chemotherapy 61: (2017).

J. Arroyo, C. Miller, J. Catalan, G.A. Myers, M.S. Ratterree, D.W. Trent, et al. ChimeriVax-West Nile virus live-

attenuated vaccine: preclinical evaluation of safety, immunogenicity, and efficacy. Journal of virology 78: 12497-

(2004).

T.P. Monath. Treatment of yellow fever. Antiviral research 78: 116-124 (2008).

S.C. Weaver, J.E. Osorio, J.A. Livengood, R. Chen, and D.T. Stinchcomb. Chikungunya virus and prospects for a

vaccine. Expert review of vaccines 11: 1087-1101 (2012).

T.W. Geisbert, C.E. Mire, J.B. Geisbert, Y.P. Chan, K.N. Agans, and F. Feldmann. Therapeutic treatment of

Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody. Science

translational medicine 6: 242ra82-242ra82 (2014).

WHO. HIV/AIDS. (2020) https://www.who.int/news-room/fact-sheets/detail/hiv-aids (accessed 12 Nov 2020).

WHO. Hepatitis B. (2020) https://www.who.int/news-room/fact-sheets/detail/hepatitis-

b#:~:text=Hepatitis%20B%20is%20a%20potentially,from%20cirrhosis%20and%20liver%20cancer. (accessed 12

Nov 2020).

WHO. Hepatitis C. (2021) https://www.who.int/news-room/fact-sheets/detail/hepatitis-c (accessed 30 Sep 2021).

R.M. Benjamin. Raising awareness of viral hepatitis: National Hepatitis Testing Day, May 19. Public Health

Reports 127: 244-245 (2012).

R.C. Burke, K.A. Sepkowitz, K.T. Bernstein, A.M. Karpati, J.E. Myers, and B.W. Tsoi. Why don't physicians test

for HIV? A review of the US literature. Aids 21: 1617-1624 (2007).

B.D. Smith, C. Jorgensen, J.E. Zibbell, and G.A. Beckett. Centers for Disease Control and Prevention initiatives

to prevent hepatitis C virus infection: a selective update. Clinical Infectious Diseases 55: S49-S53 (2012).

WHO. Screening donated blood for transfusion-transmissible infections: recommendations. World Health

Organization (2010).

E. Sagnelli, G. Starnini, C. Sagnelli, R. Monarca, G. Zumbo, E. Pontali. Blood born viral infections, sexually

transmitted diseases and latent tuberculosis in Italian prisons: a preliminary report of a large multicenter study.

Eur Rev Med Pharmacol Sci 16: 2142-6 (2012).

L.A. Scott-Sheldon, T.B. Huedo-Medina, M.R. Warren, B.T. Johnson, and M.P. Carey. Efficacy of behavioral

interventions to increase condom use and reduce sexually transmitted infections: a meta-analysis, 1991 to 2010.

Journal of Acquired Immune Deficiency Syndromes (1999) 58: 489 (2011).

J. Obiero, P.G. Mwethera, G.D. Hussey, and C.S. Wiysonge. Vaginal microbicides for reducing the risk of sexual

acquisition of HIV infection in women: systematic review and meta-analysis. BMC Infectious Diseases 12: 289

(2012).

N. Siegfried, M. Muller, J.J. Deeks, and J. Volmink. Male circumcision for prevention of heterosexual acquisition

of HIV in men. Cochrane Database of Systematic Reviews: (2009).

H. Hagan, and D.C.D. Jarlais. HIV and HCV infection among injecting drug users. Mount Sinai Journal of

Medicine 67: 423-428 (2000).

CDC. Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update

https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2017.pdf (12 Nov 2020).

CDC. Guidelines and Recommendations. (2020) https://www.cdc.gov/hiv/guidelines/index.html (accessed 12

Nov 2020).

K.H. Mayer, and K.K. Venkatesh. Antiretroviral therapy as HIV prevention: status and prospects. American

journal of public health 100: 1867-1876 (2010).

M.L. Cottrell, K.H. Yang, H.M. Prince, C. Sykes, N. White, and S. Malone. A translational pharmacology

approach to predicting outcomes of preexposure prophylaxis against HIV in men and women using tenofovir

disoproxil fumarate with or without emtricitabine. The Journal of Infectious Diseases 214: 55-64 (2016).

A.S. Omrani, and A. Freedman. Prophylaxis of HIV infection. British Medical Bulletin 73: 93-105 (2005).

D. Gold, and L. Corey. Acyclovir prophylaxis for herpes simplex virus infection. Antimicrobial agents and

chemotherapy 31: 361-367 (1987).

K. Kawamura, H. Wada, R. Yamasaki, Y. Ishihara, K. Sakamoto, and M. Ashizawa. Low‐dose acyclovir

prophylaxis for the prevention of herpes simplex virus disease after allogeneic hematopoietic stem cell

transplantation. Transplant Infectious Disease 15: 457-465 (2013).

H.S. Khurana, A. Kole, J. Falk, S. Ghandehari, G. Soohoo, and S. Simsir. Low-Dose Valganciclovir for CMV

Prophylaxis after Lung Transplantation. International Scholarly Research Notices 2013: (2013).

J.K. McGavin, and K.L. Goa. Ganciclovir. Drugs 61: 1153-1183 (2001).

H. Bayu, B. Elias, S. Abdisa, A. Tune, and H. Namo. Post exposure prophylaxis coverage, vertical transmission

and associated factors among hepatitis B exposed newborns delivered at Arsi zone health institutions, 2019. Plos

one 15: e0238987 (2020).

S. Paladini, P. Van Damme, and A.R. Zanetti. The worldwide impact of vaccination on the control and protection

of viral hepatitis B. Digestive and Liver Disease 43: S2-S7 (2011).

W.E. Levinson. Review of medical microbiology and immunology. McGraw Hill Professional (2020).

L. Piermatteo, S. D’Anna, A. Bertoli, M. Bellocchi, L. Carioti, and L. Fabeni. Unexpected rise in the circulation

of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on

HBsAg detection/quantification and vaccination strategies. Emerging Microbes & Infections 12: 2219347 (2023).

J. Leong, D. Lin, and M.H. Nguyen. Hepatitis B surface antigen escape mutations: Indications for initiation of

antiviral therapy revisited. World journal of clinical cases 4: 71 (2016).

J. Liu, A. Kosinska, M. Lu, and M. Roggendorf. New therapeutic vaccination strategies for the treatment of

chronic hepatitis B. Virologica Sinica 29: 10-16 (2014).

A. Washizaki, A. Murayama, M. Murata, T. Kiyohara, K. Yato, and N. Yamada. Neutralization of hepatitis B

virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen. Nature Communications 13:

(2022).

Y.H. Shin, C.M. Park, and C.H. Yoon. An Overview of Human Immunodeficiency Virus-1 Antiretroviral Drugs:

General Principles and Current Status. Infection & Chemotherapy 53: 29 (2021).

A. Winston, A.G. Wurcel, C. Gordon, and N. Goyal. Viral hepatitis in patients on hemodialysis. In Seminars in

dialysis. 2020. Wiley Online Library.

R. Zampino, C. Sagnelli, A. Boemio, E. Sagnelli, and N. Coppola. Treatment of chronic HBV infection in

developing countries. Annals of Hepatology 15: 816-823 (2017).

X.J. Qian, Y.Z. Zhu, P. Zhao, and Z.T. Qi. Entry inhibitors: new advances in HCV treatment. Emerging Microbes

& Infections 5: 1-8 (2016).

A.d.A. Monforte, A.C. Lepri, G. Rezza, P. Pezzotti, A. Antinori, and A.N. Phillips. Insights into the reasons for

discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral

naive patients. Aids 14: 499-507 (2000).

E.D. Belay, J.C. Kile, A.J. Hall, C. Barton-Behravesh, M.B. Parsons, and S. Salyer. Zoonotic disease programs

for enhancing global health security. Emerging infectious diseases 23: S65 (2017).

P. Olliaro, F. Fouque, A. Kroeger, L. Bowman, R. Velayudhan, A.C. Santelli, D. Garcia, R. Skewes Ramm, L.H.

Sulaiman, G.S. Tejeda, and F.C. Morales. Improved tools and strategies for the prevention and control of

arboviral diseases: A research-to-policy forum. PLoS Neglected Tropical Diseases 12: e0005967 (2018).

C.R. Parrish, E.C. Holmes, D.M. Morens, E.C. Park, D.S. Burke, and C.H. Calisher. Cross-species virus

transmission and the emergence of new epidemic diseases. Microbiology and Molecular Biology Reviews 72:

-470 (2008).

M. Rahman, M. Sobur, M. Islam, S. Ievy, M. Hossain, and M.E. El Zowalaty. Zoonotic diseases: etiology,

impact, and control. Microorganisms 8: 1405 (2020).

S. Alrashed, N. Min-Allah, I. Ali, and R. Mehmood. COVID-19 outbreak and the role of digital twin. Multimedia

Tools and Applications 81: 26857-26871 (2022).

A. Vallée. Digital twin for healthcare systems. Frontiers in Digital Health 5: 1253050 (2023).

M.N. Kamel Boulos, and P. Zhang. Digital twins: from personalised medicine to precision public health. Journal

of Personalized Medicine 11: 745 (2021).

Published

2024-04-24

How to Cite

Mohammad Ejaz, Muhammad Ali Syed, Rani Faryal, & Sheryar Jamil. (2024). Contemporary Strategies for Managing and Controlling Viral Outbreaks: An Overview: Contemporary Strategies for Managing and Controlling Viral Outbreaks. Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, 61(S). https://doi.org/10.53560/PPASB(61-sp1)1004